Choose the correct statement:
A)microsomal liver enzymes appear to have evolved to decrease the toxicity of drugs contained in plants
B)some drugs do not became psychoactive until they become ionized in the liver
C)unlike other enzymes, liver microsomal enzymes do not act on a wide variety of substances
D)the liver is the first place in which a drug can be rendered inactive

Question

Quizplus · Accepted Answer

Microsomal liver enzymes have evolved to decrease the toxicity of drugs contained in plants. This is why some drugs need to be metabolized by the liver to become active or to be rendered inactive.

Answer: D
 The liver is the main site for drug metabolism, where drugs can be rendered inactive by enzyme action or transformed into metabolites that can be excreted from the body. Therefore, the liver is the first place where the drug can be rendered inactive.

Choose the Correct Statement