The ED 50 for drugs A, B, C, and D are 10 mg, 50 mg, 100 mg, and 200 mg, respectively.The LD 50 for drugs A, B, C, and D are 100 mg, 150 mg, 500 mg, and 800 mg, respectively.Assuming the lethal dose response functions for all four drugs have the same slope, in general, which drug has the greatest margin of safety?

Question

Quizplus · Accepted Answer

The margin of safety can be calculated by dividing the LD50 by the ED50. So, for drug A, the margin of safety is 100 mg/10 mg = 10. For drug B, it is 150 mg/50 mg = 3. For drug C, it is 500 mg/100 mg = 5. And for drug D, it is 800 mg/200 mg = 4. Therefore, drug A has the greatest margin of safety.

The ED 50 for Drugs A, B, C, and D