The rate of excretion of certain acidic drugs can be enhanced by "alkalization" of the urine; also the rate of excretion for alkaline drugs can be enhanced by "acidification" of the urine.This is called
A)pH transduction
B)potentiation
C)metabolic reversal
D)ion trapping

Question

Quizplus · Accepted Answer

This phenomenon is known as "ion trapping." When the urine pH is manipulated to be either more acidic or more alkaline, it can ionize certain drugs (depending on their pKa value) and trap them in the urine, thus increasing their excretion rate. For acidic drugs, an alkaline urine pH will enhance their excretion, while for alkaline drugs, an acidic urine pH will enhance their excretion.

The Rate of Excretion of Certain Acidic Drugs Can Be