The phenomenon of "reverse tolerance" or sensitization to the effects of marijuana (THC) is most likely to be reported by humans after
A)chronic exposure to high doses of THC
B)a few exposures to high doses of THC
C)a few exposures to low doses of THC
D)chronic exposure to THC combined with alcohol

Question

Quizplus · Accepted Answer

Reverse tolerance, also known as sensitization, is more likely to occur after a few exposures to low doses of THC. This is because THC can activate the brain's reward system, leading to an increase in dopamine release. With repeated exposure, the brain may become more sensitive to the effects of THC and require smaller amounts to produce the same effects. Chronic exposure to high doses of THC may lead to tolerance, where higher doses are needed to achieve the same effects. The combination of THC and alcohol may also produce different effects than THC alone, but this is not necessarily related to reverse tolerance.

The Phenomenon of "Reverse Tolerance" or Sensitization to the Effects