Recent evidence suggests that many of the CNS effects of phencyclidine (PCP) are the result of A)blocking Ca⁺⁺ or Na⁺ flow into neurons by way of NMDA receptor/ion channels B)reducing dopamine release by activating dopaminergic autoreceptors C)blocking dopamine receptors D)all of the above

Question

Quizplus · Accepted Answer

Recent evidence suggests that the CNS effects of PCP are mainly due to blocking Ca2+ and Na+ flow into neurons by way of NMDA receptor/ion channels. This leads to an inhibition of excitatory neurotransmission, which is responsible for the major CNS effects of PCP. Reducing dopamine release or blocking dopamine receptors may also contribute to some of the effects of PCP, but they are not the primary mechanisms. Therefore, the best choice is A, blocking Ca2+ and Na+ flow into neurons by way of NMDA receptor/ion channels.

Recent Evidence Suggests That Many of the CNS Effects of Phencyclidine