Mental disorders are frequently observed in conjunction with SLE. The occurrence of psychosis in particular has been associated with

Question

Quizplus · Accepted Answer

Psychosis in SLE has been associated with the presence of autoantibodies against ribosomal P protein. These autoantibodies are thought to cross-react with neuronal antigens in the brain, leading to inflammation and dysfunction. Autoantibodies against dopamine receptors (Choice B) have also been implicated in neuropsychiatric SLE, but mainly in cases of movement disorders such as parkinsonism. Deposition of immune complexes in the choroid plexus (Choice C) and intrathecal activation of complement (Choice D) are not specific mechanisms for psychosis in SLE.

Mental Disorders Are Frequently Observed in Conjunction with SLE