The gastrointestinal tract (GIT) is a major site where the organism encounters foreign proteins from a variety of sources; therefore

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Resident T-regulatory cells play a key role in regulating the immune response in the GIT, including tolerance to dietary antigens. This helps to prevent the development of food allergies. The GIT also uses other defense mechanisms such as secretory IgA, antimicrobial peptides, and mucus production to protect against foreign proteins. Mast-cell degranulation is a key feature of allergic reactions, and can be involved in food allergies. Therefore, option A and D are incorrect. Option B is incorrect because the GIT uses a combination of defense mechanisms, not solely barrier defenses.

The Gastrointestinal Tract (GIT) Is a Major Site Where the Organism