In the early sixteenth century,Isabella d'Este,named "the First Lady of the World" by a prominent politician,ruled the city of

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Isabella d'Este was the Marchioness of Mantua in the early sixteenth century and played an important role in the cultural and artistic life of the city. She was known for her patronage of artists such as Leonardo da Vinci and Titian and for her influential correspondence with other rulers and intellectuals of the time. While she had connections to other Italian cities, including Florence and Rome, her primary base of power was in Mantua.

In the Early Sixteenth Century,Isabella D'Este,named "The First Lady of the World