The finding that people with one type of serotonin transporter gene and childhood maltreatment had higher rates of depression than either those without the gene or those with the gene without the maltreatment suggests that

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The finding suggests that both a gene and certain environmental factors (i.e. childhood maltreatment) need to be present to cause depression, indicating a gene-environment interaction. This is in line with the diathesis-stress model, which proposes that the onset of a disorder is the result of the interaction of a predisposing vulnerability (e.g. genetic factors) and stressors from the environment.

The Finding That People with One Type of Serotonin Transporter