A drug company seeking to develop a new antischizophrenic drug would want to develop a drug that reverses both positive and negative symptoms but that avoids the blockage of ________ receptors within the ________ of the schizophrenic brain.

Question

Quizplus · Accepted Answer

The dopamine D2 receptor is the main target for antipsychotic drugs and is implicated in both positive and negative symptoms of schizophrenia. However, blocking D2 receptors in the striatum can lead to motor side effects. Thus, a drug company would want to develop a drug that targets D2 receptors in areas of the brain that are not involved in motor control, such as the medial prefrontal cortex. Therefore, the best choice is D, D2 receptors in the striatum.

A Drug Company Seeking to Develop a New Antischizophrenic Drug