A drug that binds with high affinity to a receptor, but has less efficacy than the endogenous transmitter, would be termed a(n)

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A partial agonist is a drug that binds with high affinity to a receptor but has less efficacy than the endogenous transmitter. It can activate the receptor to a certain extent, but not to the same degree as a full agonist. An antagonist blocks or reduces the effects of the endogenous transmitter, while a pseudo-agonist is not a recognized term. Autoreceptor agonists and antagonists refer specifically to drugs that affect autoreceptors, which regulate the release of neurotransmitters themselves.

A Drug That Binds with High Affinity to a Receptor