In what sense could a fall in leptin levels be considered as a hunger signal?
A) Reduced leptin levels remove an inhibitory influence on NPY/AGRP neurons.
B) Leptin normally excites NPY/AGRP neurons.
C) Reduced leptin levels remove an inhibitory influence on CART/alpha-MSH neurons.
D) Leptin normally inhibits CART/alpha-MSH neurons.
E) Leptin increases the production of ghrelin.

Question

Quizplus · Accepted Answer

Leptin normally inhibits NPY/AGRP neurons, which are hunger-promoting neurons in the hypothalamus. When leptin levels fall, this inhibition is removed, allowing NPY/AGRP neurons to increase their activity, leading to hunger signals.

In What Sense Could a Fall in Leptin Levels Be