The slowness of movement noted in Parkinson's disease reflects
A) damage to frontal cortex neurons that plan motor movements.
B) damage to dopamine neurons that normally facilitate motor movements via the caudate and putamen.
C) loss of inhibition to the motor cortex.
D) damage to the primary motor cortex.
E) loss of inhibition of the ventromedial system from the GPi.

Question

Quizplus · Accepted Answer

Parkinson's disease is caused by damage to dopamine neurons in the substantia nigra, which project to the caudate and putamen. These structures form the basal ganglia, which play an important role in motor planning and movement initiation. When dopamine levels are reduced, as in Parkinson's disease, the basal ganglia cannot facilitate motor movements effectively, resulting in slowness of movement.

The Slowness of Movement Noted in Parkinson's Disease Reflects