The negative symptoms of schizophrenia, such as social withdrawal, are caused by

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The mesocortical system is responsible for cognitive and emotional processing, and damage to this system is associated with negative symptoms such as social withdrawal in schizophrenia. Underactivity of the mesolimbic system is associated with positive symptoms of schizophrenia, such as hallucinations and delusions. Excessive birth weight is not a known cause of schizophrenia. Overactivity of either the mesolimbic or the mesocortical system is not associated with negative symptoms of schizophrenia.

The Negative Symptoms of Schizophrenia, Such as Social Withdrawal, Are