PCP binds to an alternate binding site for the NMDA glutamate receptor, causing less neurotransmitter action. This binding action makes PCP a(n)
A) indirect antagonist.
B) ligand.
C) direct synergist.
D) direct antagonist.
E) neurohormone.

Question

Quizplus · Accepted Answer

PCP acts as an indirect antagonist because it binds to an alternate site on the NMDA receptor, not the primary active site, and inhibits its function, leading to decreased neurotransmitter action. This does not directly block the neurotransmitter but affects the receptor's activity indirectly.

PCP Binds to an Alternate Binding Site for the NMDA