The Holy Trinity fresco, by Masaccio, is considered to be the first painting based on the use of:

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The Holy Trinity fresco is considered to be the first painting based on the use of linear perspective, which is evident in the vanishing point on the horizon and the orthogonal lines that converge towards it. Sfumato refers to a technique of softening edges and blending colors, tenebrism to the use of strong contrasts of light and dark, and isometric perspective to a type of perspective where all sides of an object are depicted equally. None of these techniques are used in this painting.

The Holy Trinity Fresco, by Masaccio, Is Considered to Be