What was the first major disease to be prevented by inoculation?

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The first major disease to be prevented by inoculation was smallpox. Inoculation, also known as variolation, involves intentionally infecting a person with a small amount of the smallpox virus to provide immunity against the disease. This practice was first used in China in the 16th century and was introduced to Europe and North America in the 18th century. The widespread use of inoculation played a significant role in the eventual eradication of smallpox.

What Was the First Major Disease to Be Prevented by Inoculation