A client with Parkinson disease who is receiving entacapone (Comtan)is to be given epinephrine for cardiopulmonary resuscitation.The nurse should be aware that entacapone (Comtan)causes an increased effect of epinephrine on the heart due to which action?

Question

Quizplus · Accepted Answer

Entacapone (Comtan) inhibits the enzyme catechol-O-methyl transferase (COMT), which is responsible for breaking down epinephrine in the synaptic cleft. Therefore, when entacapone is present, there is an increased amount of epinephrine available to stimulate the heart. This can lead to an increased effect of epinephrine on the heart during cardiopulmonary resuscitation.

A Client with Parkinson Disease Who Is Receiving Entacapone (Comtan)is