What is the most significant difference between neostigmine and pyridostigmine?

Question

Quizplus · Accepted Answer

Neostigmine has a shorter duration of action compared to pyridostigmine. Pyridostigmine is commonly used for conditions that require long-lasting cholinergic effects, such as myasthenia gravis, whereas neostigmine is more commonly used for brief periods of cholinergic stimulation, such as during the reversal of neuromuscular blockade in anesthesia. Additionally, neither neostigmine nor pyridostigmine have no adverse effects, and both drugs can counteract neuromuscular blocking effects.

What Is the Most Significant Difference Between Neostigmine and Pyridostigmine