Why can a reduction in albumin synthesis that may occur with aging result in exaggerated effects of a medication?

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Albumin is a protein that binds to drugs in the blood, which helps to reduce their active concentrations and prevent potential side effects. A reduction in albumin synthesis with aging means that there will be less available albumin to bind with drugs, resulting in more unbound drug being present. This can lead to an increase in the pharmacological effects of the medication, potentially causing exaggerated or unexpected responses.

Why Can a Reduction in Albumin Synthesis That May Occur