In the Early 1800s,it Became Clear That the Standardization of Drug

In the early 1800s,it became clear that the standardization of drug purity and strength was necessary.Which reasons reflected this need?
Select all that apply.

A) Strength and purity of products varied from region to region and batch to batch.
B) Strength and purity of products depended on the pharmacist's experience.
C) Strength and purity of products would vary in size,taste,and nutritional value.
D) Strength and purity were mostly guaranteed if products were produced locally,which caused a hardship for those outside the region.
E) Strength and purity could be trusted when the product had gone through extensive local testing.