Potentially fatal granulocytopenia has been associated with treatment of hyperthyroidism with propylthiouracil. Patients should be taught to report:

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Potentially fatal granulocytopenia has been associated with treatment of hyperthyroidism with propylthiouracil. Patients should be taught to report fever and sore throat, as these may be early symptoms of an infection that could become severe due to the resulting decrease in granulocytes. Tinnitus and decreased salivation, hypocalcemia and osteoporosis, and laryngeal edema and difficulty swallowing are not related to propylthiouracil.

Potentially Fatal Granulocytopenia Has Been Associated with Treatment of Hyperthyroidism