Carbamazepine has a Black Box Warning recommending testing for the HLA-B*1502 allele in patients with Asian ancestry prior to starting therapy due to:
A) Decreased effectiveness of carbamazepine in treating seizures in Asian patients with the HLA-B*1502 allele
B) Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele
C) Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502 allele
D) Patients who have the HLA-B*1502 allele being more likely to have a resistance to carbamazepine
Correct Answer:
Verified
Q1: Genetic testing for VCORC1 mutation to assess
Q2: Rifampin is a nonspecific CYP450 inducer that
Q3: Genetic polymorphisms account for differences in metabolism,
Q4: Up to 21% of Asians are ultra-rapid
Q6: Pharmacogenetic testing is required by the U.S.
Q7: A provider may consider testing for CYP2D6
Q8: Patients who have a poor metabolism phenotype
Q9: A genetic variation in how the metabolite
Q10: Ultra-rapid metabolizers of drugs may have:
A) To
Q11: Warfarin resistance may be seen in patients
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