What can you infer about a high-molecular-weight protein that cannot be transported into the nucleus?
A) It is too large.
B) It lacks a nuclear localization signal (NLS).
C) It contains errors in its amino acid sequence.
D) It lacks a signal sequence.

Question

Quizplus · Accepted Answer

Nuclear localization signals (NLS) are sequences of amino acids that allow proteins to be recognized and transported into the nucleus. If a protein lacks this sequence, then it cannot be transported into the nucleus, even if it is high-molecular-weight. Therefore, option B is the best choice. Option A may also be a possibility, but it is not as specific as option B. Options C and D are not relevant to this scenario.

What Can You Infer About a High-Molecular-Weight Protein That Cannot