What would happen if an enzyme inhibitor for the enzyme phosphodiesterase (PDE) was applied to a vertebrate eye?

Question

Quizplus · Accepted Answer

When a PDE inhibitor is applied to the vertebrate eye, the cGMP-gated sodium channels in the photoreceptor cells would remain open, preventing the polarisation of these cells and glutamate discharge would be constantly released to the bipolar cells. This results in the inhibition of neurotransmitters release from the bipolar cells to the ganglion cells, which would affect visual signalling processing in the retina causing the brain to not detect light absorbed by the rod cells. This would lead to night blindness or difficulty seeing in low light conditions.

What Would Happen If an Enzyme Inhibitor for the Enzyme