Damage to the Sinoatrial Node in Humans

Damage to the sinoatrial node in humans

A) is a major contributor to heart attacks.
B) would block conductance between the bundle branches and the Purkinje fibers.
C) would have a negative effect on peripheral resistance.
D) would disrupt the rate and timing of cardiac muscle contractions.
E) would have a direct effect on blood pressure monitors in the aorta.