What is responsible for termination of transcription in eukaryotic protein-coding genes?
A) a polyadenylation, or poly(A), signal
B) a termination loop composed of guanine
C) a sigma factor
D) a portion of the polymerase holoenzyme
E) three nonsense mutations in sequence

Question

Quizplus · Accepted Answer

A polyadenylation signal (aka poly(A) signal) is responsible for termination of transcription in eukaryotic protein-coding genes. This signal is recognized by proteins that cleave the RNA transcript and add a string of adenine nucleotides to the 3' end, forming the poly(A) tail. This tail helps stabilize the mRNA and is important for its translation into protein.

What Is Responsible for Termination of Transcription in Eukaryotic Protein-Coding