Which of the following mutations is likely to cause the most dramatic phenotypic change?
A) a duplication of all or most introns
B) a large inversion whose ends are each in the same region between genes
C) a nucleotide substitution in an exon coding for a transmembrane domain
D) a single nucleotide deletion in an exon coding for an active site
E) a frameshift mutation one codon away from the 3' end of the nontemplate strand

Question

Quizplus · Accepted Answer

A single nucleotide deletion in an exon coding for an active site can drastically alter the function of the encoded protein, potentially leading to significant phenotypic changes.

Which of the Following Mutations Is Likely to Cause the Most