Pemphigus vulgaris is an autoimmune disorder in humans in which antibodies are produced against the cadherins of desmosomes. The blistering of the skin and mucous membranes characteristic of this disorder is probably a result of ________.
A) a decrease in flexibility of the cell membrane
B) an inadequate number of G-protein receptors
C) inadequate production of cytoskeletal proteins
D) a loss in cell-cell adhesion

Question

Quizplus · Accepted Answer

Pemphigus vulgaris is caused by autoantibodies that attack the cadherins of desmosomes, which are cell adhesion molecules. As a result, cell-cell adhesion is lost, which leads to the formation of blisters in the skin and mucous membranes.

Pemphigus Vulgaris Is an Autoimmune Disorder in Humans in Which