Kelley et al., (2002) used fMRI to identify specific regions of the brain that are active when people judge trait adjective are in uppercase letters, described George W. Bush, or described themselves. Compared to baseline recordings, fMRI indicated that medial prefrontal cortex (PFC) was more involved in judgments about the self than about Bush or the typeface of the letters. This indicates that the PFC is:

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The study by Kelley et al., (2002) identified the medial prefrontal cortex as a region that is more involved in judgments about the self than about other individuals or the typeface of letters. This suggests that the PFC is one of several brain regions that come into play when people think about themselves, but it is not the only region or the biological component of the self.

Kelley Et Al