Preliminary studies about the toxicity of a new drug must include the determination of the __________.

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LD50 (lethal dose 50%) is the determination of the dose of a drug that is lethal in 50% of the tested animal population. This is an important measure of toxicity and is required in preliminary studies to ensure the safety of the drug before further development and testing. ED50 (effective dose 50%) is a measure of the dose required to produce a specific effect in 50% of the population, and is not as relevant for preliminary toxicology studies. LD5 and ED5 are not as useful as LD50 and ED50 as lower doses may not provide enough information about the safety and efficacy of the drug.

Preliminary Studies About the Toxicity of a New Drug Must