The margin of safety measure of a particular drug is a more conservative (in the direction of safety) measure of drug toxicity than the therapeutic index for that drug.

Question

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The margin of safety measure takes into account the lowest dose at which toxicity occurs and compares it to the standard dose used for treatment, while the therapeutic index only considers the ratio between the therapeutic and toxic doses. Therefore, the margin of safety is a more cautious measure of drug toxicity.

The Margin of Safety Measure of a Particular Drug Is