In Fig. Img_016, which of the following familial disorders is due to abnormal development of the tissue represented in the accompanying photomicrograph?
A) Ehler-Danlos syndrome
B) Marfan syndrome
C) osteogenesis imperfecta
D) Stickler's syndrome
E) benign hypermobility syndrome

Question

In Fig. Img_016, which of the following familial disorders is due to abnormal development of the tissue represented in the accompanying photomicrograph? 
A) Ehler-Danlos syndrome 
B) Marfan syndrome 
C) osteogenesis imperfecta 
D) Stickler's syndrome 
E) benign hypermobility syndrome

Quizplus · Accepted Answer

The photomicrograph shows connective tissue with elongated, thin fibrils, which is a characteristic feature of Marfan syndrome. This disorder is caused by a mutation in the FBN1 gene, which encodes for the protein fibrillin-1, an important component of elastic fibers in connective tissue. Patients with Marfan syndrome have a range of symptoms, including tall stature, long limbs and fingers, joint hypermobility, aortic aneurysm, and lens dislocation.

In Fig Img_016, Which of the Following Familial Disorders Is Due