Acid hydrolases are synthesized on the rough endoplasmic reticulum and are delivered to the Golgi complex to be packaged and distributed to their final destination. In patients whose protooncogenes have mutated to form ras protein-related products known as ADP-ribosylation factor (ARF), this factor may interfere with
A) coatomer II (COP II) synthesis
B) coatomer II (COP II) assembly
C) coatomer II (COP II) dissociation from vesicles
D) clathrin synthesis
E) clathrin assembly

Question

Quizplus · Accepted Answer

ADP-ribosylation factor (ARF) is involved in vesicle formation, particularly in the assembly of coat proteins on vesicles, such as coatomer protein complex II (COPII). ARF can interfere with the assembly of these coat proteins, affecting the transport of proteins from the endoplasmic reticulum to the Golgi apparatus.

Acid Hydrolases Are Synthesized on the Rough Endoplasmic Reticulum and Are