Which Clients Would the Nurse Identify as Manifesting a Disease

Which clients would the nurse identify as manifesting a disease according to the GINA definition?

A) A client who has a family history of age-related macular degeneration and is losing his eyesight
B) A client whose genetic test results indicate a risk for early-onset Alzheimer disease but who has no symptoms
C) A client who discovers that both her mother and grandmother were alcoholics.
D) A client whose twin has bipolar disease and who is seeking treatment for depression
E) A child diagnosed with sickle cell anemia after bleeding into the knee