The rewarding effects of certain psychoactive drugs are related to their effects upon the nucleus accumbens in the brain.

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The nucleus accumbens is a key structure in the brain's reward pathway and is involved in the pleasurable effects of many psychoactive drugs, including drugs of abuse such as cocaine and opioids. Activation of the nucleus accumbens by these drugs is believed to be a primary mechanism underlying their rewarding effects.

The Rewarding Effects of Certain Psychoactive Drugs Are Related to Their