The margin of safety is ________ than the therapeutic index.

Question

Quizplus · Accepted Answer

Margin of safety is more conservative in the direction of safety compared to therapeutic index. Therapeutic index is a ratio of the drug dose needed to produce the desired therapeutic effect to the dose that produces toxic effects. Margin of safety, on the other hand, is a measure of the amount of drug that separates the therapeutic dose from the dose that causes toxic effects. Therefore, margin of safety provides a more conservative estimate of drug safety compared to therapeutic index.

The Margin of Safety Is ________ Than the Therapeutic Index