Tricyclic antidepressants work in the brain independently of __________.

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Tricyclic antidepressants (TCAs) work by blocking the reuptake of norepinephrine and serotonin in the brain. This is in contrast to monoamine oxidase inhibitors (MAOIs), which inhibit the enzyme monoamine oxidase, leading to an increase in the levels of serotonin, norepinephrine, and dopamine. TCAs work independently of serotonin, dopamine, and endorphins.

Tricyclic Antidepressants Work in the Brain Independently of __________