A patient newly diagnosed with Parkinson's disease has been taking levodopa/carbidopa [Sinemet] for several weeks and complains of nausea and vomiting. The nurse tells the patient to discuss what with the provider?

Question

Quizplus · Accepted Answer

Because levodopa activates the chemoreceptive trigger zone (CTZ)of the medulla,causing nausea and vomiting (N/V),the patient may need to take a lower dose temporarily until tolerance develops. A meal helps slow absorption to minimize this side effect. A high protein intake contributes to abrupt loss of effect,so meals should be low in protein. Taking a dose on an empty stomach increases absorption and also N/V. An increased dose with a high-protein snack increases N/V and also abrupt loss of effect. Dopamine increases N/V,because it activates the CTZ of the medulla.

A Patient Newly Diagnosed with Parkinson's Disease Has Been Taking