Chemical Damage to Nuclear DNA from Exposure to a Mutagenic

Chemical damage to nuclear DNA from exposure to a mutagenic agent is most dangerous when

A) the resulting mutation is repaired prior to replication of the damaged DNA.
B) the resulting mutation causes a permanent substitution of a single amino acid in an important protein with a chemically similar amino acid
C) the mutagenic agent causes a frameshift mutation near the amino terminus of a protein which promotes spermatogenesis.
D) the chemical change in the DNA results in a silent mutation which is fixed via DNA replication.
E) the resulting mutation is fixed through DNA replication and leads to the activation of a cellular oncogene and malignant transformation in a liver cell.