Gene expression can be regulated at the level of polyadenylation.

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Polyadenylation is the process of adding a poly(A) tail at the 3' end of an mRNA molecule. This modification is essential for stability and translation of the mRNA. In eukaryotes, polyadenylation can be regulated by various factors including cis-acting sequences and trans-acting factors. These factors can influence the efficiency or specificity of polyadenylation, leading to different mRNA isoforms with distinct properties. Therefore, polyadenylation represents one of the important mechanisms for post-transcriptional gene regulation in eukaryotes. In prokaryotes, however, polyadenylation is not common, and gene expression is mainly regulated at the transcriptional level.

Gene Expression Can Be Regulated at the Level of Polyadenylation