The difference in P50 values of fetal and adult hemoglobins is best explained by a difference in the

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The difference in P50 values between fetal and adult hemoglobins is primarily due to their differing interactions with 2,3-bisphosphoglycerate (2,3-BPG), an allosteric effector. Fetal hemoglobin has a lower affinity for 2,3-BPG compared to adult hemoglobin, which results in a higher affinity for oxygen, facilitating the transfer of oxygen from the mother to the fetus.

The Difference in P50 Values of Fetal and Adult Hemoglobins