The Lock and Key Model of the Active Site

The lock and key model of the active site:

A) is a conformational change brought about by the binding of inhibitor to an allosteric site.
B) is also known as cooperative binding and requires enzymes with more than one subunit.
C) does not require a conformational change for the substrate to bind to the active site.
D) is the change in the isoelectric point of an enzyme upon formation of ES complex.
E) is a conformational change evoked by binding of substrate to the active site of an enzyme.