Chloride transport through the CFTR protein is

Question

Quizplus · Accepted Answer

Chloride transport through the CFTR protein is regulated by phosphorylation and dephosphorylation of Ser residues. This is accomplished by a kinase called protein kinase A (PKA), which phosphorylates multiple Ser residues on the regulatory domain of CFTR, leading to activation of the channel. Dephosphorylation of these sites by phosphatases results in channel closure. Pharmacological agents that activate PKA, such as forskolin, can increase CFTR activity and promote chloride secretion.

Chloride Transport Through the CFTR Protein Is