Electrons from NADH produced in the cytosol by glycolysis may be transported into the mitochondrion and to the electron transport chain through which of the following compounds?

Question

Quizplus · Accepted Answer

The electrons from NADH produced in the cytosol by glycolysis may be transported into the mitochondrion and to the electron transport chain through malate. Malate-aspartate shuttle is used to transport reducing equivalents (electrons) across the mitochondrial membrane. Malate is first oxidized to oxaloacetate by the enzyme malate dehydrogenase in the presence of NAD+ in the cytosol. Oxaloacetate is then transaminated by the enzyme alanine aminotransferase to form aspartate, which can cross the mitochondrial membrane. In the mitochondrial matrix, aspartate is transaminated back to oxaloacetate, which can accept electrons to form NADH for entry into electron transport chain.

Electrons from NADH Produced in the Cytosol by Glycolysis May