Which metabolic process is most markedly impaired in the ABSENCE of insulin?

Question

Quizplus · Accepted Answer

Insulin facilitates the transportation of glucose across cell membranes by promoting the translocation of GLUT4 transporters on the cell membrane. In the absence of insulin, glucose cannot enter muscle cells efficiently, leading to hyperglycemia. Glycogenolysis and gluconeogenesis are stimulated in order to maintain glucose levels; glucose reabsorption in renal tubules is also unaffected by insulin. The use of acetoacetic acid for energy is not impaired in the absence of insulin, as it is a process primarily controlled by other hormones such as glucagon and cortisol.

Which Metabolic Process Is Most Markedly Impaired in the ABSENCE