The malate-aspartate shuttle results in the reduction of intramitochondrial

Question

Quizplus · Accepted Answer

The malate-aspartate shuttle moves reducing equivalents from the cytosol (NADH) into the mitochondria (NAD+), thereby regenerating cytosolic NAD+ and mitochondrial NADH. This is accomplished by the transfer of electrons from cytoplasmic NADH to oxaloacetate, forming malate, which can cross the mitochondrial membrane. There, malate is oxidized back to oxaloacetate, transferring the electrons to mitochondrial NAD+, generating NADH. Therefore, the shuttle results in the reduction of intramitochondrial NAD+.

The Malate-Aspartate Shuttle Results in the Reduction of Intramitochondrial