Glycolysis is only partially reversible because of energy barriers at the reactions catalyzed by

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Glycolysis is only partially reversible because of energy barriers at the reactions catalyzed by hexokinase, phosphofructokinase, and pyruvate kinase. These are key regulatory steps in the pathway, and they all involve the transfer of a phosphate group from ATP to a substrate molecule. These reactions are highly exergonic, meaning that they release a lot of energy, and they are tightly controlled to ensure that the energy is used efficiently by the cell. These energy barriers make it difficult for the reverse reactions to occur spontaneously, which is why glycolysis is not completely reversible.

Glycolysis Is Only Partially Reversible Because of Energy Barriers at the Reactions