Glucocorticoids such as cortisol and corticosterone have distinct effects on hepatic carbohydrate metabolism, such as promoting gluconeogenesis and glycogen deposition. The likely mechanism of these effects involves

Question

Quizplus · Accepted Answer

Glucocorticoids exert their effects on hepatic carbohydrate metabolism primarily by inducing new enzyme synthesis for enzymes involved in gluconeogenesis and glycogen deposition. This includes activation of transcription factors that upregulate gene expression for these enzymes. Glucocorticoids do not directly inhibit enzymes in glycolysis or glycogenesis, and their effects are not mediated through membrane receptors or acute enzyme stimulation.

Glucocorticoids Such as Cortisol and Corticosterone Have Distinct Effects on Hepatic