Export of acetyl-CoA from mitochondria to cytosol to participate in fatty acid or steroid biosynthesis involves

Question

Quizplus · Accepted Answer

Acetyl-CoA is exported from mitochondria to cytosol by forming citrate from oxaloacetate and acetyl-CoA. Citrate is then transported to cytosol by a specific antiporter, followed by its conversion back to acetyl-CoA and oxaloacetate by the enzyme ATP-citrate lyase. Acetyl-CoA can then be used in fatty acid or steroid biosynthesis. Therefore, the transport of citrate from mitochondria is required for exporting acetyl-CoA to the cytosol.

Export of Acetyl-CoA from Mitochondria to Cytosol to Participate in Fatty